In a small bowl, whisk together honey, minced garlic, soy sauce, olive oil, rice vinegar, grated ginger, and red pepper flakes until completely combined. This glaze base can be prepared up to one day ahead and refrigerated, making advance prep effortless.
Pat salmon cubes dry with paper towels and season lightly with salt and pepper. Thread three salmon pieces onto each soaked wooden skewer, leaving slight gaps between pieces for heat circulation and even cooking throughout.
Preheat your grill to medium-high heat (around 400°F) for five minutes while you prepare the glaze application station. Reserve 2 tablespoons of the honey garlic glaze separately for basting—this prevents cross-contamination and ensures food safety.
Place sticky honey garlic grilled salmon skewers directly onto oiled grill grates and cook for 4 minutes without moving them. This creates beautiful char marks while the glaze begins caramelizing beautifully on the exterior.
Carefully flip each skewer and brush the reserved glaze generously onto the cooked side. Grill for another 3-4 minutes until the salmon flakes easily with a fork and reaches 145°F internal temperature.
Transfer the honey garlic salmon skewers to a clean serving platter and immediately sprinkle with sesame seeds and fresh lime juice. The residual heat will continue cooking the fish slightly, so pull the skewers slightly before they appear fully done.
Garnish with chopped green onions and serve immediately while the glaze is still warm and tacky. Squeeze extra lime over the top just before serving for brightness that cuts through the richness.