Combine flour, instant yeast, sugar, and salt in a large mixing bowl. Whisk dry ingredients together thoroughly before adding wet components to ensure even yeast distribution.
In a separate bowl, whisk together warm milk, melted butter, egg, honey, and vanilla extract until completely combined. Pour wet mixture into dry ingredients, stirring until shaggy dough forms without dry flour spots remaining.
Knead dough for 8-10 minutes until smooth and elastic, adding flour only if sticky. The dough should be soft and slightly tacky but not sticking to your hands excessively throughout kneading.
Place dough in a greased bowl, cover with damp towel, and let rise for 60-90 minutes until doubled in size. This thanksgiving pull apart rolls crowd recipe requires proper rising time for light, fluffy results you'll be proud to serve.
Roll risen dough into a 12x8-inch rectangle on a floured surface. Spread softened butter evenly across the dough, then sprinkle cinnamon, brown sugar, and nutmeg in an even layer.
Roll dough tightly from the long side, creating a log approximately 12 inches long. Slice the roll into 12 equal pieces using a sharp, serrated knife with a gentle sawing motion.
Arrange roll pieces cut-side up in a greased 9x13-inch baking dish, nestling them close together. Cover loosely with a damp towel and let rise for 30-45 minutes until puffy and touching.
Bake in a preheated 375°F oven for 22-25 minutes until golden brown and a toothpick inserted in the center comes out clean. Remove from oven and cool in the baking dish for 5 minutes before serving warm.